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ipsc line with α-syn snca gene triplication  (Coriell Institute for Medical Research)

 
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    Coriell Institute for Medical Research ipsc line with α-syn snca gene triplication
    Ipsc Line With α Syn Snca Gene Triplication, supplied by Coriell Institute for Medical Research, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ipsc+line+with+%CE%B1-syn+snca+gene+triplication/pm39695091-92-3-17?v=Coriell+Institute+for+Medical+Research
    Average 90 stars, based on 1 article reviews
    ipsc line with α-syn snca gene triplication - by Bioz Stars, 2026-08
    90/100 stars

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    ipsc line with α-syn snca gene triplication  (Coriell Institute for Medical Research)
    90
    Coriell Institute for Medical Research ipsc line with α-syn snca gene triplication
    Ipsc Line With α Syn Snca Gene Triplication, supplied by Coriell Institute for Medical Research, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ipsc+line+with+%CE%B1-syn+snca+gene+triplication/pm39695091-92-3-17?v=Coriell+Institute+for+Medical+Research
    Average 90 stars, based on 1 article reviews
    ipsc line with α-syn snca gene triplication - by Bioz Stars, 2026-08
    90/100 stars
    		  Buy from Supplier
    ipsc line nd34391*h with α-syn snca gene triplication  (Coriell Institute for Medical Research)
    90
    Coriell Institute for Medical Research ipsc line nd34391*h with α-syn snca gene triplication
    DNA damage in neurons generated from normal and PD patient-derived SNCA-tri <t>iPSC</t> cells. A) Phase contrast image demonstrating generation of NPCs from iPSCs: (a) SNCA-tri iPSCs cultured in MEF feeder layer, (b) SNCA-tri iPSCs cultured in feeder free layer, (c) day 2, (d) day 4, (e) day 6 of neural induction for NPC derivation, (f) NPC at passage 3. The iPSC specific marker Oct4 and neural precursor markers nestin analyzed by immunoblotting (B). C) Immunofluorescence characterization with nestin <t>and</t> <t>α-Syn</t> protein expression. D) α-SYN mRNA quantitation in control versus SNCA-tri iPSC and NPC cells. E, F) LA-PCR analysis of genomic DNA isolated from control or SNCA-tri NPC cells exposed to 200 μM FeSO4 or CuSO4. ***p ≤ 0.001.
    Ipsc Line Nd34391*H With α Syn Snca Gene Triplication, supplied by Coriell Institute for Medical Research, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ipsc+line+with+%CE%B1-syn+snca+gene+triplication/pmc06172953-62-1-16?v=Coriell+Institute+for+Medical+Research
    Average 90 stars, based on 1 article reviews
    ipsc line nd34391*h with α-syn snca gene triplication - by Bioz Stars, 2026-08
    90/100 stars
    		  Buy from Supplier

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    DNA damage in neurons generated from normal and PD patient-derived SNCA-tri iPSC cells. A) Phase contrast image demonstrating generation of NPCs from iPSCs: (a) SNCA-tri iPSCs cultured in MEF feeder layer, (b) SNCA-tri iPSCs cultured in feeder free layer, (c) day 2, (d) day 4, (e) day 6 of neural induction for NPC derivation, (f) NPC at passage 3. The iPSC specific marker Oct4 and neural precursor markers nestin analyzed by immunoblotting (B). C) Immunofluorescence characterization with nestin and α-Syn protein expression. D) α-SYN mRNA quantitation in control versus SNCA-tri iPSC and NPC cells. E, F) LA-PCR analysis of genomic DNA isolated from control or SNCA-tri NPC cells exposed to 200 μM FeSO4 or CuSO4. ***p ≤ 0.001.

    Journal: Journal of Alzheimer's disease : JAD

    Article Title: Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease

    doi: 10.3233/JAD-170342

    Figure Lengend Snippet: DNA damage in neurons generated from normal and PD patient-derived SNCA-tri iPSC cells. A) Phase contrast image demonstrating generation of NPCs from iPSCs: (a) SNCA-tri iPSCs cultured in MEF feeder layer, (b) SNCA-tri iPSCs cultured in feeder free layer, (c) day 2, (d) day 4, (e) day 6 of neural induction for NPC derivation, (f) NPC at passage 3. The iPSC specific marker Oct4 and neural precursor markers nestin analyzed by immunoblotting (B). C) Immunofluorescence characterization with nestin and α-Syn protein expression. D) α-SYN mRNA quantitation in control versus SNCA-tri iPSC and NPC cells. E, F) LA-PCR analysis of genomic DNA isolated from control or SNCA-tri NPC cells exposed to 200 μM FeSO4 or CuSO4. ***p ≤ 0.001.

    Article Snippet: The iPSC line (ND34391*H) with α-Syn SNCA gene triplication ( SNCA -tri) was obtained from the CORIELL Institute cell repository.

    Techniques: Generated, Derivative Assay, Cell Culture, Marker, Western Blot, Immunofluorescence, Expressing, Quantitation Assay, Control, Isolation